- pCEL-X Software for PERMEABILITY data analysis:
PAMPA, Caco-2/MDCK, and BBB. Measured permeability data can be fitted to a biophysical model. Also, permeability profiles can be generated (using built-in databases) as a function of pH, and internally-predicted (measured, if available) ionization constants, octanol-water log P, PAMPA, Abraham Linear Free Energy Relationship (LFER) descriptors. The ionization constants are predicted at 25°C and 37°C.
- pDISOL-X Software for the analysis of DISSOLUTION
Results as a function of pH, weight of solid, solubility, ionization constants, stirring conditions, buffer capacity, etc., through microspecies simulation of concentrationn gradients in the aqueous boundary layer (ABL), using a biophysical model extension from the methods described by Mooney-Stella (1980s) and Wang-Flanagan (1990s). Partial differential equations are solved analytically, for ultra-stable (and fast) calculations.
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• INSTRUCTIONS on how to download an installation version of the program,
• PASSWORD (temporary) for accessing the server hosting the download program,
• GETTING STARTED GUIDE to demo the program’s main features.
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About in-ADME Research
in-ADME Research was founded in 2011, and has been responsible for providing unique software products and expert consulting services. Our specialty is in PHYSICOCHEMICAL PROFILING (solubility, dissolution, permeability, pKa/pH) applied to discovery and early development of drugs in pharmaceutical R&D. Our customers & clients value our expertise, something we have been collectively nourishing for nearly forty years.