in-ADME Research

Permeability and Dissolution Prediction & Analysis Software

Electrolab Physical Testing

Overview

  • pCEL-X Software for PERMEABILITY data analysis:
    PAMPA, Caco-2/MDCK, and BBB. Measured permeability data can be fitted to a biophysical model. Also, permeability profiles can be generated (using built-in databases) as a function of pH, and internally-predicted (measured, if available) ionization constants, octanol-water log P, PAMPA, Abraham Linear Free Energy Relationship (LFER) descriptors. The ionization constants are predicted at 25°C and 37°C.
  • pDISOL-X Software for the analysis of DISSOLUTION
    Results as a function of pH, weight of solid, solubility, ionization constants, stirring conditions, buffer capacity, etc., through microspecies simulation of concentrationn gradients in the aqueous boundary layer (ABL), using a biophysical model extension from the methods described by Mooney-Stella (1980s) and Wang-Flanagan (1990s). Partial differential equations are solved analytically, for ultra-stable (and fast) calculations.

Request a Free 30-day Demo

Send a business e-mail (gmail, hotmail, yahoo, etc. don’t work) to Tech-Support@in-ADME.com, containing your name, affiliation, and phone number (with area code & country code if outside USA). Acceptible requests will receive a confirmation e-mail containing:
• INSTRUCTIONS on how to download an installation version of the program,
• PASSWORD (temporary) for accessing the server hosting the download program,
• GETTING STARTED GUIDE to demo the program’s main features.

View the appropriate flyer using the links below

About in-ADME Research

in-ADME Research was founded in 2011, and has been responsible for providing unique software products and expert consulting services. Our specialty is in PHYSICOCHEMICAL PROFILING (solubility, dissolution, permeability, pKa/pH) applied to discovery and early development of drugs in pharmaceutical R&D. Our customers & clients value our expertise, something we have been collectively nourishing for nearly forty years.

READ MORE ABOUT in-ADME Reseach

The critical knowledge base for in-ADME Research has been summarized in the book written by one of the principals: Absorption and Drug Development Second Edition, Wiley, 2012. It serves as a unique resource and explores in depth the relationships between the ionization constant, solubility, and permeability as a function of pH, and applies this to the prediction of drug absorption and distribution into the brain.

in-ADME Research – View Website

PAMPA Explorer and PAMPA Evolution